Kobayakawa Sena is a little guy who always get picked on by the bullies in school. Since elementary school, he always play the role of the 'errand boy' to the extent that he has become swift and fast in his movements. Coincidentally, Hiruma Youichi and Kurita Ryukan are looking for a fast running back for their American Football team (Amefuto) and want to put Sena in the team. To hide their new 'star' player from the eyes of other High Schools, Hiruma encases Sena in a Amefuto helmet with a dark visor and name him Eyeshield #21.
The protagonist of the series is Sena Kobaykawa, a shy kid with a light physique, he is a first year at Deimon Senior High, since kindergarden he has always been the gopher of the bullies at school, to the point that he's gotten really swift and fast. Hiruma, a demon-like quarterback and Kurita, good natured lineman are the only guys on the American Football team (Deimon Devil Bats) and are desperately trying to make people join the team. After Hiruma sees Sena's running he is made join the team and becomes Eyeshield 21, wearing an eyeshield helmet to protect his identity from other teams he becomes known as "the mysterious hero from Notre Dame". In his second game he should meet his rival, Seijuro Shin, who is known as the fastest linebacker in the history of japanese football. Eventually more people will join and strengthen the team. By overcoming fears and challenges Deimon plans to win the fall tournament and beat all the teams in the kanto area.

-ANN